Professor Andrew Steptoe

Associations between social isolation, loneliness, and objective physical activity in older men and women

Changes in health and wellbeing in the years leading up to a cancer diagnosis: a prospective cohort study

Are subjective memory complaints indicative of objective cognitive decline or depressive symptoms? Findings from the English Longitudinal Study of Ageing.

Health behaviour changes after type 2 diabetes diagnosis: Findings from the English Longitudinal Study of Ageing

Depressive symptoms predict incident chronic disease burden 10 years later: Findings from the English Longitudinal Study of Ageing (ELSA)

Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing

Loneliness and social engagement in older adults: A bivariate dual change score analysis.

Vision Impairment and Risk of Dementia: Findings from the English Longitudinal Study of Ageing.

Is the relationship between subjective age, depressive symptoms and activities of daily living bidirectional?

What they say and what they do: Comparing physical activity across U.S., England, and the Netherlands

Impacts of persistent general and site-specific pain on activities of daily living and physical performance: A prospective analysis of the English Longitudinal Study of Ageing.

Key Points Question What is the association between various socioeconomic markers and dementia incidence? Findings This longitudinal cohort study found that lower wealth in late life, but not education, was associated with increased risk for dementia, suggesting that people with fewer financial resources were at higher risk. No substantive differences were identified in relation to the area of neighborhood deprivation; an age-cohort effect was observed, highlighting that socioeconomic inequalities were more robust among people born in later years. Meaning The association between socioeconomic status and dementia incidence in a contemporary cohort of older adults may be driven by wealth rather than education.

Walking Speed, Cognitive Function, and Dementia Risk in the English Longitudinal Study of Ageing.

Association of 10-year C-reactive protein trajectories with markers of healthy aging: findings from the English Longitudinal Study of Ageing.

Community group membership and multi-dimensional subjective wellbeing in older age

Social isolation, health literacy, and mortality risk: findings from the English Longitudinal Study of Ageing

Allostatic load and effort-reward imbalance: associations over the working-career

The aim of this study was to determine whether frailty in older adults is associated with the risk of subsequent dementia. A total of 8,722 older adults from the English Longitudinal Study of Ageing were followed-up every two years until they reported a diagnosis of dementia, died, or were right censored. Frailty was defined using a frailty index comprised of 47 health deficits. To test if cognitive function influences the relationship between frailty and incident dementia, the analyses were repeated according to lower or upper three quartiles of baseline cognitive function. Competing risks regression and Cox proportional hazard models were used to evaluate whether the degree of baseline frailty was associated with incident dementia. Compared with non-frail participants, pre-frail (HR: 1.51 95%CI [1.12–2.02]) and frail participants (HR: 1.73 95%CI [1.22–2.43]) had a higher risk of developing dementia, after adjustment for covariates. The association between frailty and incident dementia was significant for adults in the upper three quartiles of global cognitive function (HR: 3.48 95%CI [1.98–6.12]), but not for adults who were in the lowest quartile of cognitive function (HR: 1.13 95%CI [0.74–1.71]). Frailty should be monitored alongside cognitive functioning when assessing risk factors for dementia in older adults